Junctin - the quiet achiever

mpaired relaxation in transgenic mice overexpressing junctin

Objective: Junctin is a major transmembrane protein in cardiac junctional sarcoplasmic reticulum, which forms a quaternary complex 21 with the ryanodine receptor (Ca release channel), triadin, and calsequestrin. Methods: To better understand the role of junctin in excitation–contraction coupling in the heart, we generated transgenic mice with targeted overexpression of junctin to mouse heart, u...

The quiet revolution

Sixty years have passed since Avery, MacLeod and McCarty published their landmark paper revealing DNA as the genetic material, writes Heather Dawes.

Ageism: the quiet epidemic.

Quantifying the quiet epidemic

During the late 20 century numerical rating scales became central to the diagnosis of dementia and helped transform attitudes about its causes and prevalence. Concentrating largely on the development and use of the Blessed Dementia Scale, I argue that rating scales served professional ends during the 1960s and 1970s. They helped old age psychiatrists establish jurisdiction over conditions such ...

The Quiet Revolution

Reflections on the progress, prospects and problems of the voluntary service in mental health movement.